Cancer and Genetic Diseases

Molecular Genetics and Development

Under the direction of Marie Trudel

Research Unit

One of the main objectives of this research unit is to study molecular mechanisms that control genetic regulation and expression in transgenic mice. Scientists on this team have produced a sickle cell transgenic mouse model through a mutation in the adult beta-globin gene to study the pathophysiology of the disease and to develop effective gene therapy approaches. They are also analyzing transcriptional factors involved in the most primitive cells of hematopoietic differentiation.

Furthermore, they are characterizing the PKD1 gene responsible for polycystic kidney disease and studying the signal transduction pathway using a transgenic mouse model induced with the protooncogène c-myc.

Marie Trudel

Research Unit Director

  • Director, Molecular Genetics and Development Research Unit, IRCM
  • Full IRCM Research Professor
  • Full Research Professor, Department of Medicine (accreditation in molecular biology, and in biochemistry and molecular medicine), Université de Montréal
  • Adjunct Professor, Department of Medicine (Division of Experimental Medicine), McGill University

Degrees and relevant experience

  • PhD in biochemistry and genetics, Université Pierre et Marie Curie, Paris, France (1982)
  • Postdoctoral fellowship in genetics and mutagenesis, Imperial Cancer Research Fund, London, United Kingdom (1982-1985)
  • Postdoctoral fellowship in genetics and development, Columbia University, New York, USA (1985-1989)
Marie Trudel
Research Unit Director
Almira Kurbegovic
Postdoctoral fellow
Kevin Loayza-Vega
M.Sc. Student
Rey-Christian Pacis
MSc student
Marie-Lorna Paul
M.Sc. student
Guanham Yao
PhD student
Suganthini Faynel
Administrative Assistant


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Contact information

Montreal Clinical Research Institute (IRCM)
110, des Pins Avenue West
Montréal, Québec  H2W 1R7

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Cancer and Genetic Diseases