Translational Proteomics
- Director, Translational Proteomics Research Unit, IRCM
- Director, Biomarker Pipeline for Precision Medicine Strategic Initiative
- Full IRCM Research Professor
- Full Research Professor, Department of Biochemistry and Molecular Medicine (accreditation for the Molecular Biology Programs), Université de Montréal
- Holder of the Bell-Bombardier Chair of Excellence
Degrees and relevant experience
- PhD in molecular biology, Université de Montréal (1988)
- Postdoctoral fellowship, Banting and Best Department of Medical Research, University of Toronto (1990-1992)
- Postdoctoral fellowship, Free University of Brussels, Belgium (1992-1993)
- Assistant professor, Department of Biology, Université de Sherbrooke (1993-1996)
- Associate professor, Department of Biology, Université de Sherbrooke (1996-1999)
- Full professor, Department of Biology, Université de Sherbrooke (1999-2001)
- Full professor, Department of Biochemistry, Université de Montréal (since 2001)
Major Discoveries
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In 2007, the Coulombe lab discovered a set of previously uncharacterized proteins that turned out to play a central role in biogenesis of protein complexes and networks in human cells. Among these regulatory proteins, the PAQosome is a multisubunit cochaperone composed of an R2TP core, a PFDL module and the two associated proteins WDR92 and POLR2E/RPB5. Its R2TP core is composed of PIH1D1 and RPAP3 (in light blue) that can be replaced by homologous proteins to form alternative PAQosomes and the hexameric RUVBL1/2 module. The PFDL module contains the canonical prefoldins PFDN2 and 6 and the prefoldin-like proteins URI1, UXT, and PDRG1. Client protein complexes to be assembled by the PAQosome together with chaperones (i.e. HSP70, HSP90 and CCT) can be recruited to the PAQosome directly or indirectly via adaptors.
- Ministère de l’Économie, des Sciences et de l’Innovation du Québec
- Leducq Foundation
- Canadian Institutes for Health Research (CIHR)
- Brain Canada
- ALS Canada
- Fondation Leucodystrophie
- Montreal Clinical Research Institute (IRCM)
- IVADO
- Génome Québec