Dynamics of neuromodulatory signaling by dopamine and acetylcholine

Nicolas Tritsch, PhD
Assistant Professor
Department of Neuroscience and Physiology
New York University Grossman School of Medicine
Tritsch Lab

In person: 
IRCM Auditorium
110, avenue des Pins O, H2W 1R7 Montreal
Wearing a mask is mandatory at all times

Online:
Zoom Link : https://zoom.us/j/92279859250
ID : 922 7985 9250
Code : 658687

About this conference: 
The neuromodulators dopamine (DA) and acetylcholine (ACh) are potent regulators of behavior and have accordingly been implicated in many neuropsychiatric disorders. An important site of action for DA and ACh within the mammalian brain is the striatum, which is almost entirely composed of neurons co-expressing G protein-coupled receptors for both modulators that engage different (and sometimes antagonistic) signaling cascades. Despite this apparent convergence, the effects of DA and ACh on neural activity are often studied separately, leaving their likely cooperation in supporting brain function and dysfunction largely unexplored. I will describe our recent attempts to reveal the dynamics of extracellular DA and ACh in the striatum of mice in vivo and the mechanisms that underlie their coordination using a combination of optical, electrophysiological, molecular and genetic approaches, and will discuss the implications of our work for our understanding of how the brain motivates action and promotes learning from within.

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