. .

FH-Risk-Score

Calculator for the prediction
of cardiovascular disease
in patients with familial
hypercholesterolemia
(FH-Risk-Score)

This tool is only intended for healthcare professionals who treat patients with familial hypercholesterolemia.

Calculator

 
mmol/L
 
mmol/L
 
No Yes
 
No Yes
 
mg/dL

*The conversion factor from mg/dL to nmol/L (x2.5) can be more or less imprecise depending on the apo(a) size.

 

Disclaimers:

  • The FH-Risk-Score should be used in FH patients aged between 18 and 65 years of age.
  • The FH-Risk-Score can not be used for patients in secondary cardiovascular prevention.
  • All FH patients should be treated with maximally tolerated statin therapy regardless of the FH-Risk-Score result.
  • The cardiovascular risk should be reassessed periodically or whenever a patient’s expected risk status changes (e.g.: new onset hypertension, changes in smoking status, etc.).
  • The use of the FH-Risk-Score should not replace the clinical judgment, as several other factors that are not part of the FH-Risk-Score can modulate the clinical picture of the patient such as diabetes, lifestyle, environmental, or genetic factors, as well as the presence of inflammatory disease.
  • Consider diabetic FH subjects to have a de facto high risk of ASCVD.

Reference Publications

Paquette M, Bernard S, Cariou B, Hegele RA, Genest J, Trinder M, Brunham LR, Béliard S, Baass A. Familial Hypercholesterolemia-Risk-Score: A New Score Predicting Cardiovascular Events and Cardiovascular Mortality in Familial Hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2021 Aug 26.

Paquette M, Bernard S, Ruel I, Blank DW, Genest J, Baass A. Diabetes is associated with an increased risk of cardiovascular disease in patients with familial hypercholesterolemia. J Clin Lipidol. 2019;13(1):123-128.

Watts GF, Gidding SS, Hegele RA, Raal FJ, Sturm AC, Jones LK, Sarkies MN, Al-Rasadi K, Blom DJ, Daccord M, de Ferranti SD, Folco E, Libby P, Mata P, Nawawi HM, Ramaswami U, Ray KK, Stefanutti C, Yamashita S, Pang J, Thompson GR, Santos RD. International Atherosclerosis Society guidance for implementing best practice in the care of familial hypercholesterolaemia. Nat Rev Cardiol. 2023;20(12):845-869.

Supplemental Methods

Contact the Lipids,
Nutrition and Cardiovascular
Prevention Clinic

Dépliant sur l’hypercholestérolémie familiale
(available in French only)

PDF à télécharger

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