Director, Ruth L. and Davis S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
Originally from Quebec City, Dr. Paul Frenette received his MD from Université Laval and completed his residency and internship at Montreal General Hospital, McGill University. He moved to Boston in 1991, where he was a Clinical and Research Fellow in hematology-oncology at the New England Medical Center, then a research affiliate at the Massachusetts Institute of Technology (MIT), instructor of medicine at Harvard Medical School, associate physician at Brigham and Women’s Hospital, and a junior investigator at the Center for Blood Research. In 1998, he joined the faculty of Mt. Sinai School of Medicine, as professor of medicine, hematology and medical oncology and of gene and cell medicine. He was also a member of the school’s Stem Cell and Immunology Institutes and Cancer Center.
The author of groundbreaking studies on the stem cell microenvironment and sckle cell disease, Dr. Frenette is an elected member of the American Society for Clinical Investigation and the Association of American Physicians. He served on the editorial boards of Blood and The Journal of Clinical Investigation, as chair of the scientific committee on thrombosis and vascular biology of the American Society of Hematology, and on multiple panels at the National Heart, Lung, and Blood Institute of the National Institutes of Health. Dr. Frenette’s vascular biology interests include studies on how vascular occlusions (sudden blockages in blood vessels) occur, particularly in sickle cell anemia. His paradigm-shifting findings revised the understanding of the mechanisms involved in this complex process. By identifying the critical role played by white blood cells, his work provides potential new therapies for the diseases.