Translating T-cell biology into cellular therapies

Jean-Sébastien Delisle, MD, PhD
Associate Professor
Department of Medecine
Université de Montréal
Maisonneuve-Rosemont Hospital Research Centre

This conference is hosted by Nabil G. Seidah, PhD. This conference is part of the 2023-2024 IRCM conference calendar.

In person: 
IRCM Auditorium
110, avenue des Pins O, H2W 1R7 Montreal

About this conference
The combined advances in cellular processing/engineering and in our understanding of T-cell biology has led to revolutionary cell-based immunotherapies. The current cellular immunotherapies remain nonetheless limited by the constraints imposed by T-cell biology, ranging from antigenic recognition to the development of T-cell dysfunction. Based on early-phase clinical trial translational experience and using relevant human T-cell models inspired by clinically-compliant T-cell manufacturing systems, we have characterized how T-cell exhaustion and senescence develop in therapeutic T cells and devised approaches to improve T-cell function using cytokine signaling modulation, inhibitory co-signaling blockade and genetic engineering.

About Jean-Sébastien Delisle
    Dr. Delisle studies the aspects of T-cell biology that are most relevant to adoptive immunotherapy in humans. He leads a research program on basic and translational T-cell biology at Hôpital Maisonneuve-Rosemont and acts as Medical Director of the Centre d’excellence en thérapie cellulaire (CETC), a good-manufacturing procedure (GMP) compliant facility enabling cellular product manufacturing for clinical use. Dr. Delisle contributed to the development and implementation of several protocols used in early-phase clinical trials. Current research interests are focused on the modulation of signals that program T-cell differentiation through multiple approaches including genetic engineering in order to maximize the efficacy of adoptive immunotherapies, as well as immunomonitoring. Dr. Delisle is an FRQS-recognized clinician-scientist and a professor at the Université de Montréal.

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