Metabolic regulation of pancreatic alpha cell excitability and glucagon secretion

Matthew J. Merrins, PhD
Associate Professor 
Department of Medicine, Division of Endocrinology, Diabetes & Metabolism 
Department of Biomolecular Chemistry, University of Wisconsin-Madison

Principal Investigator 
University of Wisconsin Optical Imaging Core (UWOIC) 
University of Wisconsin-Madison School of Medicine and Public Health

This conference is hosted by Mathieu Ferron, PhD.

In person: 
IRCM Auditorium
110, avenue des Pins O, H2W 1R7 Montreal

About this conference
Diabetes mellitus is characterized by dysregulated insulin and glucagon secretion from the pancreatic islets of Langerhans. Relative to our understanding of nutrient-stimulated insulin release from pancreatic beta cells, much less is known about the metabolic regulation of glucagon secretion from pancreatic alpha cells. This seminar will discuss nutrient regulation of the alpha cell, with a focus on the mechanisms by which specific macronutrients activate and inhibit glucagon secretion. We will discuss the roles of glycolysis and the mitochondrial PEP cycle in controlling alpha cell excitability, as well as nutrient regulation of cAMP signaling and glucagon secretion. 

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