Cardiovascular and Metabolic Diseases

Translational Proteomics

Under the direction of Benoit Coulombe

Research Unit

The Translational Proteomics Research Unit, directed by Dr. Benoit Coulombe, is a pioneer in the study of the Particle for Arrangement of Quaternary structure (PAQosome, formerly RPAP3/R2TP/PFDL complex). This molecular chaperone organizes our proteome into protein complexes & networks, altogether called the interactome. The Coulombe lab and collaborators use knowledge on proteome organization and PAQosome function in an Open Science research program, named Open For Rare, aimed at developing strategies to monitor (biomarker discovery) and correct (drug discovery) assembly defects and faulty protein-protein interactions that are the cause of numerous diseases, especially rare genetic disorders such as leukodystrophies, ALS, some cancers and others.

Benoit Coulombe

Research Unit Director

  • Director, Translational Proteomics Research Unit, IRCM
  • Director, Biomarker Pipeline for Precision Medicine Strategic Initiative
  • Full IRCM Research Professor
  • Full Research Professor, Department of Biochemistry and Molecular Medicine (accreditation for the Molecular Biology Programs), Université de Montréal
  • Holder of the Bell-Bombardier Chair of Excellence

Degrees and relevant experience

  • PhD in molecular biology, Université de Montréal (1988)
  • Postdoctoral fellowship, Banting and Best Department of Medical Research, University of Toronto (1990-1992)
  • Postdoctoral fellowship, Free University of Brussels, Belgium (1992-1993)
  • Assistant professor, Department of Biology, Université de Sherbrooke (1993-1996)
  • Associate professor, Department of Biology, Université de Sherbrooke (1996-1999)
  • Full professor, Department of Biology, Université de Sherbrooke (1999-2001)
  • Full professor, Department of Biochemistry, Université de Montréal (since 2001)
Benoit Coulombe
Research Unit Director
Marie-Soleil Gauthier
Research Associate
Maxime Pinard
Research Associate
Diane Forget
Research Assistant
Philippe Cloutier
Research Assistant
Alexa Derksen
M. Sc. Student (supervisor: Dr. Geneviève Bernard)
Vijaya Madhoo
Administrative Assistant

Major Discoveries


  • Ministère de l’Économie, des Sciences et de l’Innovation du Québec
  • Leducq Foundation
  • Canadian Institutes for Health Research (CIHR)
  • Brain Canada
  • ALS Canada
  • Fondation Leucodystrophie
  • Montreal Clinical Research Institute (IRCM)
  • Génome Québec

Support biomedical research

Make a difference for health researchers and students with your donation.
Donate to the IRCM Foundation

Contact information

Montreal Clinical Research Institute (IRCM)
110, des Pins Avenue West
Montréal, Québec  H2W 1R7

Contact us
Cardiovascular and Metabolic Diseases