Cardiovascular and Metabolic Diseases

Translational Proteomics

Under the direction of Benoit Coulombe

Research Unit

The Benoit Coulombe's laboratory is deploying a high-throughput single-cell proteogenomics platform that harnesses the phage display technology to profile massively both the proteome and the transcriptome of individual cells, in a method this laboratory has named scPHAGE-seq, with the aim to track the modulations of gene expression programs with unrivaled precision along the trajectory of cells from normal to disease conditions. This information promises the design of new tools for early disease detection and treatment, before tissue damage and symptoms are present. The Coulombe laboratory is part of the 37TrillionCells initiative (www.37trillioncells.com). 

Benoit Coulombe

Research Unit Director

  • Director, Translational Proteomics Research Unit, IRCM
  • Director, Biomarker Pipeline for Precision Medicine Strategic Initiative
  • Full IRCM Research Professor
  • Full Research Professor, Department of Biochemistry and Molecular Medicine (accreditation for the Molecular Biology Programs), Université de Montréal
  • Holder of the Bell-Bombardier Chair of Excellence

Degrees and relevant experience

  • PhD in molecular biology, Université de Montréal (1988)
  • Postdoctoral fellowship, Banting and Best Department of Medical Research, University of Toronto (1990-1992)
  • Postdoctoral fellowship, Free University of Brussels, Belgium (1992-1993)
  • Assistant professor, Department of Biology, Université de Sherbrooke (1993-1996)
  • Associate professor, Department of Biology, Université de Sherbrooke (1996-1999)
  • Full professor, Department of Biology, Université de Sherbrooke (1999-2001)
  • Full professor, Department of Biochemistry, Université de Montréal (since 2001)
Benoit Coulombe
Research Unit Director
Marie-Soleil Gauthier
Research Associate
Maxime Pinard
Research Associate
Esen Sokullu
Postdoctoral Fellow
Alexa Derksen
M. Sc. Student (supervisor: Dr. Geneviève Bernard)
Vijaya Madhoo
Administrative Assistant

Major Discoveries

Publications

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Contact information

Montreal Clinical Research Institute (IRCM)
110, des Pins Avenue West
Montréal, Québec  H2W 1R7

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Cardiovascular and Metabolic Diseases