Cardiovascular and Metabolic Diseases

Translational Proteomics

Under the direction of Benoit Coulombe

Research Unit

Members of the Translational Proteomics Research Unit, directed by Benoit Coulombe, exploit the power of protein affinity chromatography and mass spectrometry to decipher novel mechanisms of transcriptional regulation by multisubunit RNA polymerases.

Benoit Coulombe's team also work to discover key regulatory factors of gene expression, elucidate the molecular defects associated to mutations in rare disease causative gene products, and develop a unique quantitative proteomics platform for the profiling of proteins and posttranslationally modified variants in patient cohorts, en route towards new generation biomarkers for precision medicine.

Benoit Coulombe

Research Unit Director

  • Director, Translational Proteomics Research Unit, IRCM
  • Director, Proteomics Discovery Research Platform
  • Full IRCM Research Professor
  • Full Research Professor, Department of Biochemistry and Molecular Medicine (accreditation for the Molecular Biology Programs), Université de Montréal
  • Holder of the Bell-Bombardier Chair of Excellence

Degrees and relevant experience

  • PhD in molecular biology, Université de Montréal (1988)
  • Postdoctoral fellowship, Banting and Best Department of Medical Research, University of Toronto (1990-1992)
  • Postdoctoral fellowship, Free University of Brussels, Belgium (1992-1993)
  • Assistant professor, Department of Biology, Université de Sherbrooke (1993-1996)
  • Associate professor, Department of Biology, Université de Sherbrooke (1996-1999)
  • Full professor, Department of Biology, Université de Sherbrooke (1999-2001)
  • Full professor, Department of Biochemistry, Université de Montréal (since 2001)
Benoit Coulombe
Research Unit Director
Philippe Cloutier
Research Assistant
Alexa Derksen
M. Sc. Student
Diane Forget
Research Assistant
Vanessa Gaspar
Postdoctoral fellow
Marie-Soleil Gauthier
Research Associate
Maxime Pinard
Research Associate
Vijaya Madhoo
Administrative Assistant


  • Ministère de l’Économie, des Sciences et de l’Innovation du Québec
  • Leducq Foundation
  • Canadian Institutes for Health Research (CIHR)
  • Brain Canada
  • ALS Canada
  • Fondation Leucodystrophie
  • Montreal Clinical Research Institute (IRCM)

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Contact information

Montreal Clinical Research Institute (IRCM)
110, des Pins Avenue West
Montréal, Québec  H2W 1R7

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Cardiovascular and Metabolic Diseases