Immunity and Viral Infections

Immune Regulation

Under the direction of Woong-Kyung Suh

Research Unit

T cells play a central role in shaping the adaptive immune system. Against non-self antigens with pathogenic threat, T cells should develop immunity. On the other hand, T cells are supposed to become tolerant to self antigens or innocuous environmental antigens. Many immunological disorders such as immunodeficiency, autoimmune diseases, and allergies are caused by T cells that fail to obey the above rules.

Members of the CD28 family cosignaling receptors and their ligands (members of B7 family) are known to play crucial roles in T cell immunity and tolerance. The Immune Regulation Research Unit's team is investigating the molecular and cellular mechanisms of CD28-B7 family of T cell cosignaling molecules using a panel of knockout, knockin, and transgenic mice. Impacts of altered T cell cosignaling are analyzed at the biochemical and cellular levels using immune cells isolated from the mice. The consequences of altered cosignaling in overall immune reactions in mice are examined in the context of infection, cancer, and autoimmunity.

Woong-Kyung Suh

Research Unit Director

  • Director, Immunity and Viral Infections Research Division, IRCM
  • Director, Immune Regulation Research Unit, IRCM
  • Associate IRCM Research Professor
  • Associate Research Professor, Department of Medicine (accreditation in the Department of Microbiology, Infectiology and Immunology, and the Molecular Biology Program), Université de Montréal
  • Adjunct Professor, Department of Medicine (Division of Experimental Medicine), and Adjunct Member, Department of Microbiology and Immunology, McGill University

Degrees and relevant experience

  • PhD in Biochemistry, University of Toronto
  • Postdoctoral fellowship in Molecular Immunology, Harvard University
  • Postdoctoral fellowship in Immunology and Cancer, Ontario Cancer Institute
Woong-Kyung Suh
Research Unit Director
Sahar Bagherzadeh Yazdchi
PhD student
Jin Sam Chang
PhD student
Joanna Li
M.Sc. Student
Vincent Panneton
PhD student
Mariko Witalis
PhD student
Alexandra Gervais
Administrative Assistant

Ongoing projects

Publications

Canadian Institutes of Health Research (MOP84544), 2012-2018
Regulation of T cell immunity by the Inducible Costimulator (ICOS)
Principal Applicant, $153,583 per year

Cancer Research Society (CRS), 2017-2019
Role of Bcl6 in disease progression of AITL, a germinal center-derived T cell lymphoma 
Principal Applicant, $60,000 per year

Support biomedical research

Make a difference for health researchers and students with your donation.
Donate to the IRCM Foundation

Contact information

Montreal Clinical Research Institute (IRCM)
110, des Pins Avenue West
Montréal, Québec  H2W 1R7

Contact us
Immunity and Viral Infections