Marlene Oeffinger's laboratory studies the regulation and dynamics of RNA maturation pathways. The main focus is to determine the temporal and spatial assembly and coordination of RNA maturation factors, as well as to identify the underlying control mechanisms that drive the processing, modification, and assembly of different RNAs.
The team, therefore, combines proteomic, RNomic, biochemical and computational approaches to build a dynamic picture of RNA maturation pathways in different cellular contexts and organisms to yield important information on how RNA maturation is linked to other cellular processes including DNA damage and repair, development as well as onset of various neurodegenerative diseases such as Alzheimer’s Disease and ALS, and how different mRNAs may require niche-ribosomes (’specialized ribosomes’) for their optimal, i.e. tissue-specific, translation.
- Director, Ribonucleoprotein Biochemistry Research Unit, IRCM
- Associate IRCM Research Professor
- Associate Research Professor, Department of Biochemistry and Molecular Medicine (accreditation in molecular biology), Université de Montréal
- Adjunct Professor, Department of Medicine (Division of Experimental Medicine), McGill University
- Research Scholar, Fonds de recherche du Québec - Santé
- New Investigator Award, Canadian Institutes of Health Research
Degrees and relevant experience
- Master’s in cell biology, University of Vienna, Austria
- PhD in molecular biology, University of Edinburgh, United Kingdom
- Postdoctoral fellowship in Dr. David Tollervey’s laboratory, University of Edinburgh, United Kingdom (2002-2003)
- Postdoctoral fellowship and research associate in Dr. Mike Rout’s laboratory, Rockefeller University, New York, USA (2003-2008 / 2008-2009)
What are we doing?
Why Ribonucleoprotein maturation pathways?
Coutinho de Oliveira L, Volpon L, Rahardjo AK, Osborne MJ, Culjkovic-Kraljacic B, Trahan C, Oeffinger M, Kwok BH, Borden KLB, Structural studies of the eIF4E-VPg complex reveal a direct competition for capped RNA: Implications for translation. - Proceedings Of The National Academy Of Sciences Of The United States Of America 2019 Nov 26
Lessard F, Igelmann S, Trahan C, Huot G, Saint-Germain E, Mignacca L, Del Toro N, Lopes-Paciencia S, Le Calvé B, Montero M, Deschênes-Simard X, Bury M, Moiseeva O, Rowell MC, Zorca CE, Zenklusen D, Brakier-Gingras L, Bourdeau V, Oeffinger M, Ferbeyre G, Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway. - Nature Cell Biology 2018 Jul
Burlacu E, Lackmann F, Aguilar LC, Belikov S, Nues RV, Trahan C, Hector RD, Dominelli-Whiteley N, Cockroft SL, Wieslander L, Oeffinger M, Granneman S, High-throughput RNA structure probing reveals critical folding events during early 60S ribosome assembly in yeast. - Nature Communications 2017 Sep 28
BioTechnology Focus - Canadian researchers discover a new and direct molecular mechanism to stop cancer cells from proliferating.
Planet Today News - Researchers have found a new way that could inhibit the growth of cancerous cells.
Healthcare in Europe - Canadian researchers have found a promising way to stop tumour cells from multiplying.
Support biomedical research
Montreal Clinical Research Institute (IRCM)
110, des Pins Avenue West
Montréal, Québec H2W 1R7