Systems Biology and Medicinal Chemistry

Ribonucleoprotein Biochemistry

Under the direction of Marlene Oeffinger

Research Unit

Marlene Oeffinger's laboratory studies the regulation and dynamics of RNA maturation pathways. The main focus is to determine the temporal and spatial assembly and coordination of RNA maturation factors, as well as to identify the underlying control mechanisms that drive the processing, modification, and assembly of different RNAs. 

The team, therefore, combines proteomic, RNomic, biochemical and computational approaches to build a dynamic picture of RNA maturation pathways in different cellular contexts and organisms to yield important information on how RNA maturation is linked to other cellular processes including DNA damage and repair, development as well as onset of various neurodegenerative diseases such as Alzheimer’s Disease and ALS, and how different mRNAs may require niche-ribosomes (’specialized ribosomes’) for their optimal, i.e. tissue-specific, translation.

Marlene Oeffinger

Research Unit Director

  • Director, Ribonucleoprotein Biochemistry Research Unit, IRCM
  • Associate IRCM Research Professor 
  • Associate Research Professor, Department of Biochemistry and Molecular Medicine (accreditation in molecular biology), Université de Montréal
  • Adjunct Professor, Department of Medicine (Division of Experimental Medicine), McGill University
  • Research Scholar, Fonds de recherche du Québec - Santé
  • New Investigator Award, Canadian Institutes of Health Research

Degrees and relevant experience

  • Master’s in cell biology, University of Vienna, Austria
  • PhD in molecular biology, University of Edinburgh, United Kingdom
  • Postdoctoral fellowship in Dr. David Tollervey’s laboratory, University of Edinburgh, United Kingdom (2002-2003)
  • Postdoctoral fellowship and research associate in Dr. Mike Rout’s laboratory, Rockefeller University, New York, USA (2003-2008 / 2008-2009)
Marlene Oeffinger
Research Unit Director
Lisbeth-Carolina Aguilar
Research Assistant
Pierre Bensidoun
PhD student
Mathew Kramar
PhD Student
Priyanka Prabhala
PhD Student
Ulises Rodriguez Corona
Postdoctoral fellow
Christian Trahan
Research Associate
Vijaya Madhoo
Administrative Assistant

Ongoing projects

Publications

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Contact information

Montreal Clinical Research Institute (IRCM)
110, des Pins Avenue West
Montréal, Québec  H2W 1R7

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Systems Biology and Medicinal Chemistry