Systems Biology and Medicinal Chemistry

Stem Cells and Cell Reprogramming

Under the direction of Mohan Malleshaiah

Research Unit

How do individual cells process information to make decisions? 

Cells transition from one functional state to another and the associated heterogeneity are fundamental to development, disease, differentiation and reprogramming. Cells use molecular networks to sense and process the environmental information to make specific decisions. We are interested in understanding how cells use transcriptional and signaling networks. Our research is driven by twin motivations: to understand the nature and function of networks that cells have evolved; and, apply this knowledge to either control or engineer (reprogram) cells for useful purpose, such as creating better stem cells and driving the cells away from a disease state.

We study pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells. To better elucidate the logic of decision making at individual cell level, we use quantitative single-cell measurements, including single-cell genomics and proteomics. In combinations with experiments, we use computational biology and mathematical modeling to better interpret the data and generate predictive models which can be further verified by experiments.

Our lab provides an interdisciplinary collaborative environment to pursue science. The lab members come from diverse fields such as cell biology, computational biology, biochemistry, systems biology, physics and engineering.

We are currently pursuing specific projects focused on the following themes:

  1. Pluripotent stem cell heterogeneity and its significance
  2. Cell state specific configuration and reconfiguration of regulatory networks
  3. Information flow through cell signaling networks
  4. Cellular reprogramming to generate cells with totipotency
  5. Cell state specific regulation of gene expression

Mohan Malleshaiah

Research Unit Director

  • Director, Stem Cells and Cell Reprogramming Research Unit, IRCM
  • Assistant Research Professor, IRCM
  • Assistant Research Professor, Department of Biochemistry and Molecular Medicine, Université de Montréal

Degrees and relevant experience

  • PhD in Biochemistry, Department of Biochemistry and Molecular Medicine, Université de Montréal, Canada.
  • Postdoctoral Fellow, Department of Systems Biology, Harvard Medical School, Boston, USA
  • Research Associate, Aurigene Discovery Technologies Ltd., Bangalore, India
  • M.Sc. in Biotechnology, Department of Microbiology and Biotechnology, Bangalore University, India
  • B.Sc. in Microbiology, SBM Jain College, Bangalore University, India
Mohan Malleshaiah
Research Unit Director
Loïck Joumier
Étudiant à la maîtrise
Thulaj Meharwade
PhD Student
Adrien Sprumont
Étudiant à la maîtrise en médecine cellulaire et moléculaire (MCM)
Mélanie Candido
Administrative Assistant

Publications

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Contact information

Montreal Clinical Research Institute (IRCM)
110, des Pins Avenue West
Montréal, Québec  H2W 1R7

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Systems Biology and Medicinal Chemistry