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		ResearchOur research
Researchers
Knowledge Transfer
Scientific Integrity
PlatformsOur platforms
Animal Facilities and Animal Health
Bioinformatics
Molecular Biology and Functional Genomics
Flow Cytometry
Histology
Disease Modeling and Genome Editing
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Research
Researchers

IRCM Researchers
Creating new

knowledgeExploring new avenues to develop tomorrow’s medical knowledge through an approach that integrates basic and clinical research
Our research units are led by principal investigators who collaborate in a spirit of collegiality and with the vision of bridging the gap between research and patients. They train the next generation of scientists and are independent and creative minds who work tirelessly to improve health.
 
Alexis

BaassDirector, Lipids, Nutrition and Cardiovascular Prevention Clinic
Current research"With our research, we want to develop precision medicine in order to offer personalized care to each of our patients with lipid disorders."Alexis Baass,  Director, Lipids, Nutrition and Cardiovascular Prevention Clinic
PresentationThe health care professionals at the genetic lipids and dyslipidemia clinic assess and treat patients with high blood cholesterol and/or triglyceride levels and genetic lipid diseases. Dr. Baass' research team studies the nutritional, biochemical, genetic, molecular, and pharmacological aspects of genetic dyslipidemias (among others, familial hypercholesterolemia, chylomicronemia syndromes and dysbetalipoproteinemia) to improve the screening, diagnosis, and treatments of these diseases. Which allows them to offer personalized care and reduce the associated cardiometabolic complications.
 
FH-Risk-Score
Au cœur des lipides (podcasts in French)
Available positions  Clinical studies 


	
			Team
		

			Habiba OUESLATI Adjointe administrative Administrative Assistant Habiba.Oueslati@ircm.qc.ca 
Khiem NGUYEN Adjoint administratif Administrative Assistant Khiem.Nguyen@ircm.qc.ca 
Martine PAQUETTE Gestionnaire Manager Martine.Paquette@ircm.qc.ca 
Michel Bikuki Beya Technicien en administration Administrative Technician michel.bikuki.beya@ircm.qc.ca 
Nathalie SAINT-PIERRE Coordonnatrice de recherche, Infirmière Research Coordinator, Nurse Nathalie.Saint-Pierre@ircm.qc.ca 
Sébastien Duchesne Infirmier Nurse Sebastien.Duchesne@ircm.qc.ca 
Simon-Pierre Guay Stagiaire sans crédit Uncredited Intern simon-pierre.guay@ircm.qc.ca 

		




	
			Affiliations
		

			Director of the Lipids, Nutrition and Cardiovascular Prevention Clinic, Montreal Clinical Research Institute (IRCM)
Director of the Genetic Dyslipidemia Clinic, Montreal Clinical Research Institute (IRCM)
Medical biochemist and lipidologist
Assistant Professor in the Department of Medicine, Division of Medical Biochemistry of the McGill University Health Center MUHC.
Associate Member of the Division of Endocrinology, McGill University Health Center (MUHC)
Member of the Medical Biochemistry Division, McGill University Health Center (MUHC)
Medical biochemist supervising the Protein Laboratory (electrophoresis and nephelometry) and HPLC (HbA1C) of the Royal Victoria Hospital of the McGill University Health Center (MUHC)
Associate member of the Centre Hospitalier de l'Université de Montréal (CHUM) Department of medical biochemistry


		




	
			Degrees and experience
		

			Specialist's certificate from the Province of Quebec 
Post doctorate, DES Medical Biochemistry, Royal College of Physicians and Surgeons of Canada, Université de Montréal 
Fellowship, FRCP(C) Medical Biochemistry, Royal College of Physicians and Surgeons of Canada 
M.Sc. with thesis, Biomedical Sciences, Montreal Clinical Research Institute (IRCM)
Postdoctoral Fellowship in Lipidology, Montreal Clinical Research Institute (IRCM)
Licentiate of the Medical Council of Canada 
Residency in Medicine, Medical Biochemistry, University of Montreal
Doctorate, MD, Medicine, University of Montreal
Research internship in biochemistry, McGill University 
B.Sc. in Biochemistry, McGill University


		




	
			Publications
		

			Zobaida Al-Baldawi MSc, Leslie Brown BSc, Isabelle Ruel PhD, Alexis Baass MDMSc, Jean Bergeron MD MSc, Lubomira Cermakova MSc, Patrick Couture MD PhD, Daniel Gaudet MD PhD, Gordon A. Francis MD, Robert A. Hegele MD, Iulia Iatan MD PhD, G.B. John Mancini MD, Brian W McCrindle MD MPH, Thomas Ransom MD MSc, Mark H. Sherman MD, Ruth McPherson MD PhD, Jacques Genest MD, Liam R. Brunham MD PhD. Sex Differences in the Presentation, Treatment and Outcomes of Patients with Homozygous Familial Hypercholesterolemia. Journal of Clinical Lipidology, 14 January 2024
Paquette M, M. Sc. Blais C, RD. Fortin A, RD. MSc. Bernard S, MD, PhD. Baass A, MD, M.Sc. Dietary recommendations for dysbetalipoproteinemia: A need for better evidence. J Clin Lipidol. 2023 May 25.
De Villers-Lacasse A, Paquette M, Baass A, Bernard S. Non-alcoholic fatty liver disease in patients with chylomicronemia syndromes. J Clin Lipidol. 2023 May 20.
Paquette M, Bernard S, Cariou B, Hegele RA, Genest J, Trinder M, Brunham LR, Béliard S, Baass A. Metabolic syndrome predicts cardiovascular risk and mortality in familial hypercholesterolemia. J Clin Lipidol. 2023 Mar 22.
Paquette M, Faubert S, Saint-Pierre N, Baass A, Bernard S. Sex differences in LDL-C response to PCSK9 inhibitors: A real world experience. J Clin Lipidol. 2022 Dec 8.
Paquette M, Bernard S, Baass A. Dysbetalipoproteinemia is associated with increased risk of coronary and peripheral vascular disease. J Clin Endocrinol Metab. 2022 Dec 17.
Paquette M, Carrié A, Bernard S, Cariou B, Hegele RA, Genest J, Trinder M, Brunham LR, Béliard S, Baass A. Effect of the LDL receptor mutation type on incident major adverse cardiovascular events in familial hypercholesterolaemia. Eur J Prev Cardiol. 2022 Nov 15.
 Paquette M, Bernard S, Baass A. Diagnosis of remnant hyperlipidaemia. Curr Opin Lipidol. 2022 Aug 1.
Doiron S, Paquette M, Baass A, Bollée G, Cardinal H, Bernard S. Association between circulating PCSK9 and proteinuria in nephrotic syndrome: A cross-sectional study. Clin Biochem. 2022 Aug 5.
Heidemann BE, Koopal C, Baass A, Defesche JC, Zuurbier L, Mulder MT, Roeters van Lennep JE, Riksen NP, Boot C, Marais AD, Visseren FLJ. Establishing the relationship between familial dysbetalipoproteinemia and genetic variants in the APOE gene. Clin Genet. 2022 Aug 22.
Hassanloo J, Béland-Bonenfant S, Paquette M, Baass A, Bernard S. Prevalence, severity, and management of hypertriglyceridemia-associated pancreatitis; A 7-year retrospective cohort study at Canadian quaternary care hospitals. J Clin Lipidol. 2022 May 21.
Fantino M, Paquette M, Blais C, Saint-Pierre N, Bourque L, Baass A, Bernard S. Both low-fat and low-carbohydrate diets reduce triglyceride concentration in subjects with multifactorial chylomicronemia syndrome: a randomized crossover study. Nutr Res. 2022 Feb 18. 
Paquette M, Bernard S, Paré G, Baass A. Dysbetalipoproteinemia: Differentiating Multifactorial Remnant Cholesterol Disease from Genetic ApoE Deficiency. J Clin Endocrinol Metab. 2022 Jan 18.
Paquette M, Baass A. Polygenic risk scores for cardiovascular disease prediction in the clinical practice: Are we there? Atherosclerosis. 2021 Dec 5.
Roy G, Couture P, Genest J, Ruel I, Baass A, Bergeron J, Brisson D, Brunham LR, Cermakova L, Gaudet D, Khoury E, Laflamme N, Kennedy BA, Hegele RA, Drouin-Chartier JP. Influence of the LDL Receptor Genotype on Statin Response in Heterozygous Familial Hypercholesterolemia: Insights from the Canadian FH Registry. Can J Cardiol. 2021 Nov 11.
Kastberg SE, Lund HS, De Lucia-Rolfe E, Kaduka LU, Boit MK, Corpeleijn E, Friis H, Bernard S, Paquette M, Baass A, Rasmussen JJ, Christensen DL. Hepatic steatosis is associated with anthropometry, cardio-metabolic disease risk, sex, age, and urbanisation, but not with ethnicity in adult Kenyans. Trop Med Int Health. 2021 Nov 7.
Paquette M, Bernard S, Baass A. Hemoglobin concentration, hematocrit and red blood cell count predict major adverse cardiovascular events in patients with familial hypercholesterolemia. Atherosclerosis. 2021 Sep 15.
EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). Lancet. 2021 Sep 7.
Paquette M, Bernard S, Cariou B, Hegele RA, Genest J, Trinder M, Brunham LR, Béliard S, Baass A. Familial Hypercholesterolemia-Risk-Score: A New Score Predicting Cardiovascular Events and Cardiovascular Mortality in Familial Hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2021 Aug 26.
Paquette M, Baass A. Response by Paquette and Baass to Letter Regarding Article, "Familial HypercholesterolemiaRisk-Score: A New Score Predicting Cardiovascular Events and Cardiovascular Mortality in Familial Hypercholesterolemia". Arterioscler Thromb Vasc Biol. 2021 Nov 23.
Paquette M, Fantino M, Bernard S, Baass A. Paternal inheritance predicts earlier cardiovascular event onset in patients with familial hypercholesterolemia. Atherosclerosis. 2021 Jun 11.
Fantino M, Paquette M, Bernard S, Baass A. ANKS1A genotype predicts cardiovascular events in patients with familial hypercholesterolemia. J Clin Lipidol. 2021 May 30.
Paquette M, Amyot J, Fantino M, Baass A, Bernard S. Rare Variants in Triglycerides-Related Genes Increase Pancreatitis Risk in Multifactorial Chylomicronemia Syndrome. J Clin Endocrinol Metab 2021 Aug 18.
Béland-Bonenfant S, Paquette M, Fantino M, Bourque L, Saint-Pierre N, Baass A, Bernard S. Montreal-FH-SCORE Predicts Coronary Artery Calcium Score in Patients with Familial Hypercholesterolemia. CJC Open. 2020 Sep 14.
Trinder M, Paquette M, Cermakova L, Ban MR, Hegele RA, Baass A, Brunham LR. Polygenic Contribution to Low Density Lipoprotein Cholesterol Levels and Cardiovascular Risk in Monogenic Familial Hypercholesterolemia. Circ Genom Precis Med. 2020 Aug 13 .
Aljenedil S, Alothman L, Bélanger AM, Brown L, Lahijanian Z, Bergeron J, Couture P, Baass A, Ruel I, Brisson D, Khoury E, Gaudet D, Genest J. Lomitapide for treatment of homozygous familial hypercholesterolemia: The Québec experience. Atherosclerosis. 2020 Aug 5.
Paquette M, Fantino M, Bernard S, Baass A. The ZPR1 genotype predicts myocardial infarction in patients with familial hypercholesterolemia. J Clin Lipidol. 2020 Jul 24.
Paquette M, Bernard S, Blank D, Paré G, Baass A. A simplified diagnosis algorithm for dysbetalipoproteinemia. J Clin Lipidol. 2020 Jun 10.
Paquette M, Gauthier D, Chamberland A, Prat A, De Lucia Rolfe E, Rasmussen JJ, Kaduka L, Seidah NG, Bernard S, Christensen DL, Baass A. Circulating PCSK9 is associated with liver biomarkers and hepatic steatosis. Clin Biochem. 2020 Mar 
Paquette M, Bernard S, Paré G, Baass A. Triglycerides, hypertension, and smoking predict cardiovascular disease in dysbetalipoproteinemia. J Clin Lipidol. 2020 Jan – Feb.
Baass A, Paquette M, Bernard S, Hegele RA.Familial chylomicronemia syndrome: an under-recognized cause of severe hypertriglyceridaemia. J Intern Med. 2020 Apr. 
Garg A, Fazio S, Duell PB, Baass A, Udata C, Joh T, Riel T, Sirota M, Dettling D, Liang H, Garzone PD, Gumbiner B, Wan H. Molecular Characterization of Familial Hypercholesterolemia in a North American Cohort. J Endocr Soc. 2019 Nov.
Paquette M, Bernard S, Thanassoulis G, Baass A. LPA genotype is associated with premature cardiovascular disease in familial hypercholesterolemia. J Clin Lipidol. 2019 Jul - Aug. 
Lorenzatti AJ, Eliaschewitz FG, Chen Y, Lu J, Baass A, Monsalvo ML, Wang N, Hamer AW, Ge J. Randomised study of evolocumab in patients with type 2 diabetes and dyslipidaemia on background statin: Primary results of the BERSON clinical trial. Diabetes Obes Metab. 2019 Jun. 
Paquette M, Bernard S, Baass A. SLC22A3 is associated with lipoprotein (a) concentration and cardiovascular disease in familial hypercholesterolemia. Clin Biochem. 2019 Feb 14. 
Paquette M, Bernard S, Hegele RA, Baass A. Chylomicronemia: Differences between familial chylomicronemia syndrome and multifactorial chylomicronemia. Atherosclerosis. 2018 Dec 28.
Brunham LR, Ruel I, Aljenedil S, Rivière JB, Baass A, Tu JV, Mancini GBJ, Raggi P, Gupta M, Couture P, Pearson GJ, Bergeron J, Francis GA, McCrindle BW, Morrison K, St-Pierre J, Henderson M, Hegele RA, Genest J, Goguen J, Gaudet D, Paré G, Romney J, Ransom T, Bernard S, Katz P, Joy TR, Bewick D, Brophy J. Canadian Cardiovascular Society Position Statement on Familial Hypercholesterolemia: Update 2018. Can J Cardiol. 2018 Dec.
Paquette M, Bernard S, Ruel I, Blank DW, Genest J, Baass A. Diabetes is associated with an increased risk of cardiovascular disease in patients with familial hypercholesterolemia. J Clin Lipidol. 2018 Sep 17.
Brunham LR, Ruel I, Khoury E, Hegele RA, Couture P, Bergeron J, Baass A, Dufour R, Francis GA, Cermakova L, Mancini GBJ, Brophy JM, Brisson D, Gaudet D, Genest J. Familial hypercholesterolemia in Canada: Initial results from the FH Canada national registry. Atherosclerosis. 2018 Oct.
Paquette M, Baass A. A Novel Cause of Familial Hypercholesterolemia: PCSK9 Gene Duplication. Can J Cardiol. 2018 Oct.
Ruel I, Brisson D, Aljenedil S, Awan Z, Baass A, Bélanger A, Bergeron J, Bewick D, Brophy JM, Brunham LR, Couture P, Dufour R, Francis GA, Frohlich J, Gagné C, Gaudet D, Grégoire JC, Gupta M, Hegele RA, Mancini GBJ, McCrindle BW, Pang J, Raggi P, Tu JV, Watts GF, Genest J. Simplified Canadian Definition for Familial Hypercholesterolemia. Can J Cardiol. 2018 Sep.
Baass A, Hegele RA. Getting Real With PCSK9 Inhibitors in Familial Hypercholesterolemia. Can J Cardiol. 2018 Aug
Lorenzatti AJ, Eliaschewitz FG, Chen Y, Fialkow J, Lu J, Baass A, Monsalvo ML, Hsu HC, Somaratne R, Ge J. Rationale and design of a randomized study to assess the efficacy and safety of evolocumab in patients with diabetes and dyslipidemia: The BERSON clinical trial. Clin Cardiol. 2018 Sep.
Paquette M, Hegele RA, Baass A. PCSK9 inhibitors in familial hypercholesterolemia: What is the evidence? J Clin Lipidol. 2018 Sep - Oct.
Paquette M, Dufour R, Baass A. PHACTR1 genotype predicts coronary artery disease in patients with familial hypercholesterolemia. J Clin Lipidol. 2018 Jul - Aug;12(4):966-971.
Paquette M, Baass A. Genetic Regulation of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Plasma Levels: Another Piece of the Puzzle. Circ Genom Precis Med. 2018 May.
Paquette M, Baass A. Predicting cardiovascular disease in familial hypercholesterolemia. Curr Opin Lipidol. 2018 Aug.
Paquette M, Saavedra YGL, Poirier J, Théroux L, Dea D, Baass A, Dufour R. Loss-of-Function PCSK9 Mutations Are Not Associated With Alzheimer Disease. J Geriatr Psychiatry Neurol. 2018 Mar. 
Paquette M, Hegele RA, Paré G, Baass A. A novel mutation in GPIHBP1 causes familial chylomicronemia syndrome. J Clin Lipidol. 2018 Mar - Apr. 
Paquette M, Genest J, Baass A. Familial hypercholesterolemia: experience from the French-Canadian population. Curr Opin Lipidol. 2018 Jan 19.
Paquette M, Dufour R, Baass A. ABO blood group is a cardiovascular risk factor in patients with familial hypercholesterolemia. J Clin Lipidol. 2017 Dec 14.


		


Ongoing projectsSeveral ongoing pharmacological clinical trials in patients with hypertriglyceridemia, hypercholesterolemia or high lipoprotein (a) value.
Ongoing projects
Several ongoing pharmacological clinical trials in patients with hypertriglyceridemia, hypercholesterolemia or high lipoprotein (a) value.
Important Discoveries
Tools
 


	
			Press review
		

			
		




	
			Press review
		

			
		




	
			Grants
		

			Several funds from pharmaceutical companies, including studies initiated by the companies or by our research group.
Canadian Institutes of Health Research (CIHR) Cardiometabolic Health, Diabetes and Obesity
Research Network (CMDO) Yvan Morin Foundation


		




	
			Recognitions and honors
		

			
		



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IRCM Researchers

Creating new knowledge

Alexis Baass

Current research

"With our research, we want to develop precision medicine in order to offer personalized care to each of our patients with lipid disorders."

Presentation

Ongoing projects

Ongoing projects

Important Discoveries

Tools

Join the group Research

Available positions

Ongoing clinical studies

Research Partners

Join the research group

Life in the laboratory

Discoveries, events and more

Be part of the solution

Research

Platforms

Student life

Admissions

The Institure

Events

The Clinic

Careers

Contact us

News

Newsroom

Creating new
knowledge

Alexis
Baass

Join the
group Research

Join the
research group

Life in the
laboratory

Discoveries,
events and more

Be part of the
solution
