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Creating new
knowledge
Exploring new avenues to develop tomorrow’s medical knowledge through an approach that integrates basic and clinical research
Our research units are led by principal investigators who collaborate in a spirit of collegiality and with the vision of bridging the gap between research and patients. They train the next generation of scientists and are independent and creative minds who work tirelessly to improve health.
Current research
"We want to understand how functional plasticity of RNA-protein complexes affects the etiology of neurodegenerative diseases."
Marlene Oeffinger, research director
Ribonucleoprotein Biochemistry
Marlene Oeffinger's laboratory studies the regulation and dynamics of RNA maturation pathways. The main focus is to determine the temporal and spatial assembly and coordination of RNA maturation factors, as well as to identify the underlying control mechanisms that drive the processing, modification, and assembly of different RNAs.
The team, therefore, combines proteomic, RNomic, biochemical and computational approaches to build a dynamic picture of RNA maturation pathways in different cellular contexts and organisms to yield important information on how RNA maturation is linked to other cellular processes including DNA damage and repair, development as well as onset of various neurodegenerative diseases such as Alzheimer’s Disease and ALS, and how different mRNAs may require niche-ribosomes (’specialized ribosomes’) for their optimal, i.e. tissue-specific, translation.
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Ongoing Research
RNA machines : assembly, structure and functional plasticity
Using affinity purification (AP) and mass spectrometry (MS) and cross-linking approaches to determine the stoichiometry, intra-complex architecture, substrates and functional plasticity of nuclear RNA binding proteins along different RNA metabolism pathways.
Nucleolar stress and rDNA damage
Dissecting the nucleolar DNA damage network using AP-MS and CRISPR-screens.
Functional Plasticity & Disease
Determining the functional adaptation and alteration of RNA-Protein complexes – or RNA machines – in response to mutations, cell stress, tissue differences and their links to neurodegenerative disease.
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