Acetyl-CoA metabolism in health and disease

Kathryn E. Wellen, PhD
Professor
Department of Cancer Biology
University of Pennsylvania - Perelman School of Medicine
Wellen Lab
Philadelphia, PA, USA

This conference is hosted by Jennifer Estall, PhD. This conference is part of the 2022-2023 IRCM conference calendar.

In person: 
IRCM Auditorium
110, avenue des Pins O, H2W 1R7 Montreal
Wearing a mask is mandatory at all times

Online:
Zoom Link : https://zoom.us/j/95269762104
ID : 952 6976 2104
Code : 476372

IRCM conferences are set to occur under a hybrid format. However, please note that last-minute changes to online-only lectures may occur due to unforeseen circumstances. We invite you to visit this webpage again a few days before attending.

About this conference: 
Acetyl-CoA is a central metabolic intermediate used for lipid synthesis in the cytosol and histone acetylation in the nucleus, processes with crucial roles in physiology, as well as in metabolic diseases and cancer. The two major precursors to acetyl-CoA are citrate and acetate, which are processed to acetyl-CoA by ATP-citrate lyase (ACLY) and acyl-CoA synthetase short-chain 2 (ACSS2), respectively. In this presentation, I will discuss our work on the roles and regulation of these acetyl-CoA metabolic enzymes in nutrient handling in liver and adipose tissue and implications for systemic metabolic homeostasis. I will also present new evidence for an additional metabolic route that can be leveraged to supply acetyl-CoA for lipid synthesis and histone acetylation.

About Kathryn E. Wellen:
Dr. Kathryn Wellen is a Professor and the Vice-Chair of the Department of Cancer Biology at the University of Pennsylvania Perelman School of Medicine, and an Investigator at the Abramson Family Cancer Research Institute. The focus of her research aims to elucidate acetyl-CoA metabolism, notably how the enzymes that produce this molecule are regulated, how they affect histone acetylation and lipid metabolism, as well as how these processes impact health and disease. The work of Dr. Wellen has been published in top journals such as Nature, Nature Communications, Molecular Cell, Science Advances, and Cancer Research.

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