Diabetes, obesity and osteoporosis are growing health issues in western countries. The Molecular Physiology Research Unit aims to understand the molecular and physiological mechanisms underlying these metabolic disorders, with the long-term goal of developing novel therapeutic approaches.
The team is also more generally interested in identifying and characterizing new inter-organ relationships implicated in normal physiology or in pathological conditions.
For instance, the current research focus includes characterizing the biological roles of vitamin K in glucose homeostasis and metabolism, in bone health and in coagulation, and understanding the functions of osteocalcin, a recently identified hormone produced by bones that affects energy metabolism.
- Director, Cardiovascular and Metabolic Diseases Research Division, IRCM
- Director, Molecular Physiology Research Unit, IRCM
- Associate IRCM Research Professor
- Associate Research Professor, Department of Medicine (accreditation in molecular biology, and in biochemistry and molecular medicine), Université de Montréal
- Canada Research Chair holder in Bone and Energy Metabolism
- Adjunct Professor, Department of Medicine, Division of Experimental Medicine, McGill University
- Member, Montreal Diabetes Research Center
- Member, CMDO
- Member, RSBO
Awards and honours
- Jean-Davignon/Novo Nordisk Young Investigator Award 2020, Research Network on Cardiometabolic Health, Diabetes and Obesity (CMDO)
- Étoiles Effervescence Award 2019
- 2017 Pierre-Bois Excellence Award, IRCM Foundation
- 2014 Early Investigators Award, Endocrine Society
- Helmsley Charitable Trust Abstract Award in type 1 diabetes (2014), Endocrine Society
- The Endocrine Society Outstanding Abstract Award (2013), Endocrine Society
- K99/R00 Pathway to Independence Award 2012-2013, National Institute of Diabetes and Digestive and Kidney Diseases
- ASBMR John Haddad Young Investigator Award 2011
Degrees and relevant experience
- B.Sc., Department of Biochemistry, Université de Montréal (1998)
- PhD in molecular biology, Department of Medicine, Université de Montréal (2006)
- Postdoctoral fellowship, Department of Genetics and Development, Columbia University, New York, USA (2006-2011)
- Research Associate, Department of Genetics and Development, Columbia University, New York, USA (2011-2013)
2017: Identification of furin proprotein convertase as a key regulator of bone endocrine function
2017: Link between osteocalcin carboxylation and insulin resistance in humans
2015: Role of gamma-carboxylation in bone endocrine function
2013: Demonstration that osteoclasts regulate glucose metabolism in vivo
Leanza G, Fontana F, Lee SY, Remedi MS, Schott C, Ferron M, Hamilton-Hall M, Alippe Y, Strollo R, Napoli N, Civitelli R, Gain-of-Function Lrp5 Mutation Improves Bone Mass and Strength and Delays Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes. - Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2021 Jul
Suchacki KJ, Morton NM, Vary C, Huesa C, Yadav MC, Thomas BJ, Turban S, Bunger L, Ball D, Barrios-Llerena ME, Guntur AR, Khavandgar Z, Cawthorn WP, Ferron M, Karsenty G, Murshed M, Rosen CJ, MacRae VE, Millán JL, Farquharson C, PHOSPHO1 is a skeletal regulator of insulin resistance and obesity. - BMC Biology 2020 Oct 22
Abu-Thuraia A, Goyette MA, Boulais J, Delliaux C, Apcher C, Schott C, Chidiac R, Bagci H, Thibault MP, Davidson D, Ferron M, Veillette A, Daly RJ, Gingras AC, Gratton JP, Côté JF, AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network. - Nature Communications 2020 Jul 17
Lacombe J, Al Rifai O, Loter L, Moran T, Turcotte AF, Grenier-Larouche T, Tchernof A, Biertho L, Carpentier AC, Prud'homme D, Rabasa-Lhoret R, Karsenty G, Gagnon C, Jiang W, Ferron M, Measurement of bioactive osteocalcin in humans using a novel immunoassay reveals association with glucose metabolism and β-cell function. - American Journal Of Physiology. Endocrinology And Metabolism 2020 Jan 14
ICI Première (Les années lumières) – Mathieu Ferron explains why our bones help regulate appetite.
Radio-Canada - A team led by Mathieu Ferron has uncovered the mechanism that allows bones to respond to sugar in our blood.
ICI Première (Médium large) - Mathieu Ferron's team has demonstrated how osteocalcin, a hormone produced by our bones that could influence the development of diabetes in some people, is activated before being released into the bloodstream.
- Diabète Québec (2017)
- Natural Sciences and Engineering Research Council of Canada (2016-2021)
- Canadian Institutes of Health Research (2013-2019) (2018-2023)
- Canada Research Chair tier 2 (2013-2018)
- J.A. de Sève Foundation (2014-2016)
- Diabète Québec-MDRC (2014)
- John R. Evans Leaders Fund, Canada Foundation for Innovation (2013)