Mechanisms of Genetic Diversity
The Mechanisms of Genetic Diversity Research Unit studies the molecular biology and physiology of antibody responses. The major area of the research program studies the function and regulation of the enzyme Activation induced deaminase (AID), expressed in B lymphocytes. This enzyme is unique because it can directly make mutations in the genome. Normally, it mutates the immunoglobulin genes to initiate the mechanisms of somatic hypermutation and class switch recombination, which change the antibody affinity and function. We study these mechanisms and the regulation of AID, to understand how it is kept in check to prevent collateral damage that can be oncogenic and cause B cell lymphomas.
The research in this area has direct implication for human disease and vaccination strategies.
A second area of the research program studies a recently discovered enzyme belonging to the same family of AID, which is likely to participate in the metabolism of deoxynucleotides, the building blocks of DNA. This metabolism is limiting for cell proliferation and has implications in cancer, the metabolism of certain anticancer drugs, and the efficiency of viral infections.
- Associate Vice-President, Student Affairs
- Director, Mechanisms of Genetic Diversity Research Unit, IRCM
- Full IRCM Research Professor
- Full Research Professor, Department of Medicine (accreditation in biochemistry and molecular medicine; molecular biology; and microbiology, infectiology and immunology), Université de Montréal
- Adjunct Professor, Department of Medicine (Division of Experimental Medicine), McGill University
- Canada Research Chairholder in Genetic Diversity
Degrees and relevant experience
- PhD in biochemistry, University of Buenos Aires, Argentina (2000)
- M.Sc. in biological sciences, University of Buenos Aires, Argentina (1994)
- Postdoctoral fellowship, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom (2001-2006)
Discovery of a pathway regulating cytoplasmic AID stability
Discovery of the mechanisms regulating AID subcellular localization
Discovery of a mechanism linking AID with DNA repair
Uncovering the relevance of the uracil DNA-glycosylase UNG in germinal centers
Rodríguez-Cortez VC, Martínez-Redondo P, Català-Moll F, Rodríguez-Ubreva J, Garcia-Gomez A, Poorani-Subramani G, Ciudad L, Hernando H, Pérez-García A, Company C, Urquiza JM, Ramiro AR, Di Noia JM, Vaquero A, Ballestar E, Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites. - Scientific Reports 2017 Aug 8
UdeM Nouvelles - As a representative of the IRCM's Master's option in Molecular and Cellular Medicine, Javier Di Noia receives UdeM’s Award of Excellence for Innovation.
- Canadian Institutes of Health Research (CIHR)
- Canadian Cancer Society Research Institute
- Lymphoma and leukemia society of Canada
Support biomedical research
Montreal Clinical Research Institute (IRCM)
110, des Pins Avenue West
Montréal, Québec H2W 1R7