Participate in a clinical study

Take part in scientific research

Fundamental research can lead to the development of new diagnostic approaches or treatments that need to be evaluated for effectiveness and safety through clinical trials. These studies are the ultimate and necessary step before allowing their use. 

At the IRCM, our doctors and researchers are responsible for several clinical studies in which you can participate. Each study is evaluated and accepted by a research ethics committee. After obtaining your consent, you will be strictly monitored by a team of professionals, including nurses and doctors. Since it is often new techniques or molecules that have not been used in humans, we must monitor potential effects that cannot always be predicted.
 
If you want to participate in studies, do not hesitate to talk to your doctor or you can consult the list of current studies.

Electrocardiographic changes during hypoglycemia

The IRCM Clinic is seeking volunteers for a research project on the study of people with type 1 diabetes with cardiovascular disease. The objective of the study is to measure the impact of spontaneous hypoglycemia on the heart.

Financial compensation will be given. The project is being carried out under the supervision of Dr. Rémi Rabasa-Lhoret and Dr. Hélène Mansaray.

This study involves a visit to the IRCM clinic for approximately two hours. We will ask you to wear a Holter (device which measures your heart’s rhythm) and a Freestyle Libre continuous glucose monitor for 48 hours.

Inclusion criteria

  • Clinical diagnosis of type 1 diabetes for at least 6 months
  • Be over 18 years of age
  • Have either a history of cardiovascular disease or more than 30 years of diabetes

Informations

Marie Raffray, Nurse
514 987-5770
marie.raffray@ircm.qc.ca

Dr. Hélène Mansaray
helene.mansaray@ircm.qc.ca

Evaluation of the effect of FIASP ultra-fast acting insulin

The IRCM clinic is seeking volunteers for a research project on the comparison of ultra-fast acting insulin (FIASP) and fast acting insulin (Novorapide) on blood glucose excursions during the exercise following a meal. 

Financial compensation will be given. The project is being carried out under the supervision of Dr. Rémi Rabasa-Lhoret.

Inclusion criteria

  • Clinical diagnosis of type 1 diabetes for at least 1 year
  • Be over 18 years of age
  • On the multiple daily injections mode of treatment (basal/bolus)

This study involves a total of five visits, including one admission visit and four intervention visits. The admission visit lasts about two hours and a meeting with the doctor will determine your eligibility to participate in the study. 

Intervention visits last about five hours. Breakfast will be served in the morning and two different strategies will be tested: one-hour cycling one hour after the meal, and two hours after the meal.

Informations

Inès Boukabous, Kinesiologist
514 987-5657
ines.boukabous@ircm.qc.ca

Comparison of two diets for the treatment of severe hypertriglyceridemia

The IRCM clinic is looking for patients with very high blood triglyceride levels (severe hypertriglyceridemia) to compare the effect of a low-fat diet to a low sugar diet on triglyceride reduction. Each participant will have to follow the two diets in random order, for a period of three weeks each. Menus and recipes will be provided for these two diets, as well as compensation for parking fees related to the visits. In addition, a nutritionist will be available throughout your participation in the study.

The study is being conducted under the supervision of Dr. Sophie Bernard, Director of the IRCM Lipids Clinic.

Inclusion criteria

  • Men or women, 18 years old or over
  • Have already had a triglyceride value equal or higher than 10 mmol/L

This study involves four visits over an 11-week period and two telephone follow-ups.

Informations

Manon Fantino, Dt.P., Master's student
514 987-5650
manon.fantino@ircm.qc.ca

Survey on behaviours and attitudes related to nutrition and body image

The purpose of this study is to validate a survey on eating disorders in adult patients with type 1 diabetes. You do not need to have an eating disorder to participate in this study. Your participation in the study consists of answering a web survey via the SimpleSurvey® platform, which takes approximately 30 minutes to complete.

Inclusion criteria

  • Adults with type 1 diabetes

Complete the survey online.

Informations

Danijela Bovan, nurse
514 987-5617
danijela.bovan@ircm.qc.ca

Andréanne Fortin, dietitian
514 987-5589
andreanne.fortin@ircm.qc.ca

Reducing exercise-induced hypoglycemia

The IRCM Clinic is seeking pstients with type 1 diabetes to participate in a research project assessing the efficacy of reducing basal insulin to reduce exercise-induced hypoglycemia in adolescents and adults with type 1 diabetes. This study aims to test strategies to reduce the risk of exercise-induced and post-exercise hypoglycemia.

A financial compensation will be given for each intervention completed. The project is being conducted under the supervision of Dr. Laurent Legault (Montreal Children’s Hospital), Dr. Rémi Rabasa-Lhoret (IRCM) and Dr. Mélanie Henderson (Centre hospitalier universitaire Sainte-Justine).

Inclusion criteria

  • Have type 1 diabetes for at least 2 years
  • Be over 14 years old
  • Use insulin pump therapy for more than 3 months

This study involves 3 visits that can be undertaken over 3 months. A first visit to determine your eligibility to participate in the study will take place at the IRCM. The duration of this visit is approximately three hours. Subsequently, two intervention visits to test two strategies to reduce exercise-induced hypoglycemia: reducing basal insulin by 80% 90 minutes before exercise onset, and reducing basal insulin by 80% 40 minutes before exercise onset. Each intervention involves a 3.5 hours stay at the IRCM. 

The efficacy of two strategies applied after exercise to reduce the risk of post-exercise hypoglycemia will be assessed with reduced insulin basal rate after exercise and reduced insulin bolus with dinner, and post-exercise snack, regular insulin bolus at dinner and an evening snack.

Informations

Sémah Tagougui, Postdoctoral Fellow
514 987-5500, ext. 3295
semah.tagougui@ircm.qc.ca

 

Treatment of hypoglycemia and type 1 diabetes

The IRCM Clinic is seeking patients with type 1 diabetes to participate in a research project on the treatment of mild to moderate hypoglycemia in adults with type 1 diabetes. 

Participants in the research project will have the opportunity to acquire knowledge that will enable them to improve their treatment. Financial compensation will be given for each intervention completed. The project is being conducted under the supervision of Dr. Rémi Rabasa-Lhoret and Dr. Sylvie Ott-Braschi.

Inclusion criteria

  • Have had type 1 diabetes for more than one year
  • Be over 18 years old
  • Use insulin pump or multiple insulin injections

This study involves five visits that can extend over six months. A first visit is made to the research centre to determine your eligibility. This visit lasts about 3 hours. Subsequently, four visits to test two treatments to correct hypoglycemia induced at two different blood sugar levels:

  • 16 g carbohydrate treatment when blood glucose is less than 3.0 mmol/L
  • 32 g carbohydrate treatment when blood glucose is less than 3.0 mmol/L
  • 16 g carbohydrate treatment when blood glucose is between 3.0 and 3.5 mmol/L
  • 32 g carbohydrate treatment when blood glucose is between 3.0 and 3.5 mmol/L

Informations

Virginie Messier, Project Coordinator
514 987-5500, ext. 3227
virginie.messier@ircm.qc.ca

Type 2 diabetes and hypercholesterolemia

The IRCM Clinic is looking for patients with familial hypercholesterolemia and patients who are taking statins for more than 5 years to participate in a clinical study at IRCM. The aim of this study is to examine the function of the fat tissue as well as other health conditions that may affect the risk for type 2 diabetes in these patients.

Participants will receive compensation for the time and expenses associated with this study. The project is being conducted under the supervision of May Faraj, Director of the Nutrition, Lipoproteins and Cardiovascular Diseases Research Unit. All relevant findings from the study will be provided to the patients and may be forwarded to their family physician.

Inclusion criteria

  • Man; from 45 to 74 years old
  • Postmenopausal woman; from 45 to 74 years old (without hormone therapy replacement)
  • Non-smoking
  • Without diabetes
  • Available for the duration of the study (one visit per week, for 6 weeks)

Informations

Marie Devaux, Nurse
514 987-5500, ext. 3314
marie.devaux@ircm.qc.ca 

Study aiming at reducing the risk of diabetes

The IRCM Clinic is looking for adult volunteers to participate in a clinical study aiming at the prevention of type 2 diabetes. The project examines the effects of omega-3 supplements on reducing newly-discovered risk factors for type 2 diabetes. Being involved in this study provides volunteers an in-depth medical examination in addition to obtaining information relevant to their state of health, including: their risk of developing type 2 diabetes, their body composition in terms of muscle mass, percentage of fat and bone density, their number of calories spent at rest, etc.

The project is being conducted under the supervision of May Faraj, Director of the Nutrition, Lipoproteins and Cardiovascular Diseases Research Unit.Participants will receive financial compensation for their time and expenses related to this study.

Inclusion criteria

  • Man; from 45 to 74 years old
  • Postmenopausal women; from 45 to 74 years old (without hormone therapy replacement)
  • Non-smoking
  • Without diabetes or heart diseases
  • Available for the duration of the study (7 one-hour visits and 4 one-day visits, spread over 18 weeks)

Informations

Marie Devaux, Nurse
514 987-5500, ext. 3314
marie.devaux@ircm.qc.ca

Evaluation of the efficacy of the artificial pancreas

The IRCM clinic is seeking volunteers to participate in the research project evaluating the efficacy of the external artificial pancreas in preventing hypoglycemia and maximizing time of glucose levels spent in target range in adults with type 1 diabetes.

Inclusion criteria

  • Clinical diagnosis of type 1 diabetes for at least 1 year
  • Be over 18 years of age
  • Has been on insulin pump therapy for at least three months

This study involves at least two clinic visits lasting two to four hours. A first visit of about four hours takes place at the research centre to determine the eligibility of the participant. Thereafter, at least one additional visit will take place to explain how to use the artificial pancreas. 

  • One admission visit
  • A 12-day period with the artificial pancreas and a CGM (continuous glucose monitor). 
  • A 12-day period with the users' current pump and CGM.
  • Three or four telephone calls during the 12-day periods and staff available on-call for 24-hour.

The admission visit involves a three- to four-hour period to ensure that participants are well trained on the artificial pancreas system.

Informations

Marie Raffray, Nurse
514 987-5770
marie.raffray@ircm.qc.ca

The BETTER project for type 1 diabetes

The BETTER project aims to develop a registry of individuals living with type 1 diabetes in Quebec to better characterize the causes, experience and consequences of hypoglycemia. Do you have the disease? Sign up now!

Visit the BETTER website